Restoring Hormonal Balance
JangoBio is developing regenerative therapies to reverse hormone imbalances associated with aging and thereby mitigate the risk of developing a wide range of age-related diseases. Pharmaceutical treatments, such as hormone supplementation, do not address the underlying loss of function, and can have significant side effects.
The Importance of Hormone Balance
As our bodies transition from reproductive maturity to middle-age, a milieu of circulating reproductive hormones begin to fall out of balance. These hormones maintain tissues in the body, and imbalance can lead to disease. Men experience a gradual decline in hormone levels beginning at age 30. Women experience changes leading up to menopause, after which hormone levels diverge dramatically. Hormone imbalance is caused by the loss of gonadal cells and their function ('hypogonadism'). The standard treatment with single hormones, such as testosterone or estrogen, does not address this underlying deficit. Our solution is to restore function to gonadal tissues and the spectrum of circulating hormones.
Implication for Age-Related Disease
Imbalance of circulating hormones is associated with the development of age-related diseases and increased mortality. For example, longitudinal studies in patients with hypogonadism demonstrate that these patients are at greater risk of dying sooner and developing age-related conditions, such as Alzheimer's disease, Type II diabetes, and osteoporosis. Additionally, recent studies in rodents demonstrate that blood-borne factors present in young animals can restore health and vitality to aged animals. Treatment of hormone imbalance has the potential to treat intractable age-related diseases.
Living healthier lives longer
Advancements in medical practice and procedures have reduced mortality from a range of diseases, enabling people to live longer lives. This long-lived demographic, however, presents new challenges to society and to the healthcare system due to growing incidence of age-related diseases. For this reason, there is a need to extend the portion of an individuals life where they remain healthy. New treatment modalities that overcome the limitations of pharmaceuticals are needed in order to achieve this goal. JangoBio offers a new paradigm for restoration of tissue function and improving health.